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          多肽藥物

            “多肽藥物”創新團隊2011年入選教育部“長江學者和創新團隊發展計劃”。團隊以甘肅省新藥臨床前研究重點實驗室、“985”醫藥學科科技創新平臺等科研平臺為依托,是一支由“長江學者”特聘教授作為學術帶頭人,以優秀中青年研究學者為骨干的多學科交叉、優勢互補的高水平創新研究隊伍,具有較強的綜合科技實力,并已取得了一系列高水平基礎和應用研究成果,在本研究領域中處于領先地位,在國內外具有一定的學術影響力。

            研究團隊緊密地圍繞多肽藥物研究的主題,致力于解決限制多肽藥物發展和應用的核心問題,目前已建立了從上游非天然氨基酸結構單元的合成、多肽藥物修飾和大規模合成,到下游多肽藥物信號轉導通路和作用機制研究的完善體系。通過化學、生物學、醫學、藥學等多學科合作與交叉,在基礎和應用研究中取得了突出成績。入選以來,團隊已發表SCI論文84篇,申請國家發明專利8件,已授權2件。承擔了“重大新藥創制”國家科技重大專項、國家自然科學基金重點項目、國家杰出青年科學基金等多項科研項目。

          團隊負責人簡介

            王銳,男,漢族,1963年生,博士,中國工程院院士。現任蘭州大學校長助理、基礎醫學院院長、甘肅省新藥臨床前研究重點實驗室主任,兼任全國政協委員、甘肅省人大常委、甘肅省歐美同學會·留學人員聯誼會會長。

            1978年考入蘭州大學,1988年獲博士學位(蘭州大學與日本京都大學聯合培養),蘭州大學和美國堪薩斯大學(University of Kansas)博士后。蘭州大學教授、博士生導師,教育部“長江學者”特聘教授,國家杰出青年科學基金獲得者,中組部國家“萬人計劃”領軍人才,負責“多肽藥物”教育部創新團隊和科技部十一五、十二五“重大新藥創制”國家重大科技專項多肽關鍵技術課題。

            他率領團隊圍繞制約多肽新藥創制的關鍵科學和技術問題,進行了系統的創新性研究,取得了突出成績,通過從新合成方法到新制備技術的連續創新努力,推動了我國多肽新藥創制及產業化的發展。

            他作為第一完成人榮獲國家自然科學獎二等獎、國家技術發明獎二等獎、省部級一等獎4項、國際學術獎勵3項、何梁何利科學與技術創新獎。

            他以通訊作者發表SCI論文影響因子大于2的321篇,其中一區論文113篇,影響因子大于10的22篇,單篇最高影響因子50.95,論文被引用1萬余次,H指數(H-index)為50,連續三年入選Elsevier“中國高被引學者”,成果被Nature引用并亮點報道。獲國家發明專利授權35件,申請國際專利PCT 4件,多項技術用于多肽新藥研發與生產,獲中國專利獎。

            他在教書育人和人才培養方面做出了重要貢獻,為我國培養了一批德才兼備的多肽科學與產業領域的優秀人才。在學科建設中發揮了重要作用,在蘭州大學藥學與毒理學、生物學與生物化學、化學三個學科分別進入美國ESI前1%或前1‰中做出了突出貢獻。

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